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Brand name: solifenacin
Generic name: vesicare, solifenacin, Vesitrim, Vesikur
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According to the product labeling, coadministration of solifenacin (10 mg) with the potent CYP450 3A4 inhibitor ketoconazole (400 mg) resulted in a 1. Before taking Solifenacin succinate, make sure the doctor knows if you have liver or kidney disease, stomach or intestinal problems, severe constipation, eyes problems such as glaucoma, or a heart condition called prolonged QT interval. 7-fold increase in the systemic exposure (AUC) compared to administration of solifenacin alone. MANAGEMENT: Pharmacologic response to solifenacin should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the solifenacin dosage adjusted if necessary. 5-fold increase in the mean solifenacin peak plasma concentration (Cmax) and a 2. You must use caution when driving, operating machinery, or engaging in hazardous activities when taking Solifenacin succinate to prevent injury to yourself and others.

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